Concept of Cross-Protection and Herd Immunity 

Basic Vaccine Immunology 

 

LEARNING DISCUSSION 

08 November 2023 

14:30 – 14:50H 

 

Speaker:

Jin Oh Kim  

MSD AP Region 

 

Description:

Herd protection is usually defined as Immunization of large portions of the population to protect the unvaccinated, immunocompromised, and immunologically naive by reducing the number of susceptible hosts to a level less than the threshold needed for transmission”.  

Key topics will be 1. Definition of herd immunity and implications in community protection; 2. Examples of herd immunity in some selected vaccines; 3. Key parameters in herd immunity and threshold in various vaccines; 4. Vaccine hesitancy, COVID-19 Impact and measles outbreaks; 5. Herd Immunity and COVID-19 

Cross-protection is defined as clinically significant protection against infection/disease due to an immune response elicited against a related organism. 

Key topics will be 1. Cross-reactivity and cross-protection; 2. Cross protections in various vaccines; 3. Example of cross-protection approach in developing universal flu vaccine; 4. Cross-protection and COVID-19